Methyl Methyl Cinnamate: The Best Raw Material for Anti-thrombosis Ozagrel Sodium

Thrombosis is a solid substance formed by the deposition, coagulation, and coagulation of blood components in the heart or part of the blood vessels of living animals. It is a small piece of blood flow formed on the surface of the blood vessels in the cardiovascular system where the blood vessels are peeled off or repaired. The incidence of thrombosis is high and even more harmful. According to statistical data, the number of deaths caused by stroke and myocardial infarction with thromboembolism in our country is 2.6 million each year, and the average number of deaths is 21 per second. Thrombosis is an "uninvited guest" in the blood. It can stop the flow of blood in the "river channel" and cause severe ischemia in the corresponding organs at the far end, resulting in a series of disabling consequences and even death. Thrombosis is a head-to-toe, systemic disease with a wide range of onset. It can affect lower limbs, visceral vessels, and carotid arteries of the upper extremities. Myocardial infarction can occur when a thrombus occurs in the heart; Cerebral infarction can occur when it occurs in the head; Deep venous thrombosis and arterial thrombosis can occur in the lower limbs.

At present, the treatment of thrombosis is mainly antithrombotic therapy using thrombolytic drugs, antiplatelet drugs and anticoagulants. Ozagrel sodium is a commonly used antithrombotic agent that works well. However, Ozagrel's oral effect is not good, and the injection effect is good.

The traditional method for the preparation of sodium ozagrel is low in yield, complicated in steps, and this is a direct cause of the more expensive sodium ozagrel. The in-depth and repeated studies of existing people have found that the use of methyl cinnamate in the synthesis of sodium ozagrel is simple and the yield is high, which can directly reduce the price of drugs and reduce the economic burden on patients. The specific operation is methyl brommethyl cinnamate prepared by bromination of methyl p-methyl cinnamate by N-bromosuccinimide, and methyl bromomethyl cinnamate in N-butyl ionic liquid. The pyridinium tetrafluoroborate is alkaline hydrolyzed with imidazole after room temperature condensation to obtain the antithrombotic drug Ozagrel sodium with a total yield of 67%.